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It was first patented to treat malaria in 1999 by Glaxo Wellcome, which merged with another British pharmaceutical company called SmithKline Beecham in 2000 to form the pharmaceutical giant GlaxoSmithKline

State of global tobacco Yet, because of an ever growing population, the number of smokers is still enormous

What started as a bottom-up community of micro-manufacturers and early adopter vapers (as distinct from smokers) by around 2007 began to attract the interest of Big Tobacco who embarked on a programme of developing their own products and taking over some of the original starts-up

Leos forward-looking spirit is clearly reflected in the S500, a guitar he designed for players who share that spirit